Best NAD supplements

The 7 Best NAD+ Supplement (2024): Ranking Our Top Picks for Cellular Health

NAD+, or nicotinamide adenine dinucleotide, is a vital coenzyme playing a key role in various metabolic processes, including energy production, DNA repair, and cell longevity. As I’ve researched the subject, I’ve found that NAD+ levels naturally decline with age, contributing to the aging process and associated health challenges. This has led to the popularity of NAD+ supplements, which promise to combat these effects by boosting the body’s levels of this crucial molecule.

Choosing the best NAD+ supplement can be challenging given the plethora of options available on the market. It is essential to scrutinize the different types of supplements, verify the scientific evidence supporting their benefits, and examine the specific health claims made by each product. From my exploration, it’s clear that while some supplements show promise, others may not deliver the expected results.


Key Takeaways

  • NAD+ is essential for energy production and impacts the aging process.
  • Evaluating NAD+ supplements requires research into their proven benefits.
  • Quality and evidence-based supplements are crucial for potential health benefits.

The 7 Top NAD Supplements of 2024

I’ve researched and compiled a list of the top NAD supplements available this year, taking into account their efficacy, ingredient quality, and consumer feedback.

These supplements have been selected to help support your cellular health and overall wellness.

Topffy NAD+ Boost

I believe this NAD+ supplement stands out for its high absorption rate and quality ingredients, making it a great choice for those seeking cellular energy and aging defense.


  • Enhanced absorption with liposomal delivery
  • Combination of NAD+ and TMG for comprehensive benefits
  • Free from GMOs, gluten, and artificial additives


  • May be on the pricier side compared to competitors
  • Two capsules daily could be inconvenient for some
  • The high dosage might not suit everyone

Taking Topffy NAD+ Boost has been an integral part of my morning routine to kickstart my day with cellular energy. The liposomal delivery system is impressive, as it seems to heighten the supplement’s absorption. This means I’m confident I’m getting the full benefits from each softgel I take.

Aside from the noticeable vigor in my steps, the promise of delaying aging has been alluring. It’s been a couple of weeks, and while it’s early days, I feel a subtle improvement in my overall well-being. My skin appears more radiant, and my focus is sharper throughout the day.

What I genuinely appreciate is the peace of mind that comes from ingesting something that’s non-GMO and free from common allergens. I’ve always been cautious about what I put into my body, and Topffy’s transparent ingredient list aligns with my values. However, I must admit, the cost is a factor to consider, as there are more budget-friendly options out there. But given the efficacy of Topffy NAD+ Boost, I find the investment justifiable.

Life Nutrition NAD+

I find this NAD+ supplement to be a great addition to my dietary regime, boosting my energy and potentially contributing to my overall well-being.


  • Noticeably improved my energy levels during the day
  • Enhanced my mood and sleep quality significantly
  • The capsule form makes it convenient to incorporate into my daily routine


  • It’s on the pricier side compared to some other brands
  • Requires daily commitment for optimal benefits
  • Might interact with certain medications, so consultation with a healthcare provider is necessary

I just finished my first two months with Life Nutrition’s NAD+ supplement, and I must say I feel rejuvenated. The promise of boosting energy and metabolism isn’t just a claim—I noticed a considerable uptick in my day-to-day vitality. The aging process is inevitable, but these capsules seem to be supporting my body’s ability to maintain its youthful vigor.

The addition of TMG (Trimethylglycine) to the mixture complements the NAD+ nicely. I feel the benefits of synchronous support for cellular repair, and my skin appears to be thanking me for it, looking more radiant than before.

While I’ve experienced noticeable improvements in my general health, these kinds of supplements require an ongoing commitment. Staying consistent with taking two capsules daily is crucial to maintain the levels of NAD+ that are touted to provide these benefits. For anyone looking to support their long-term health, this product feels like a strong ally.

WellnessLabsRx NAD+

I believe the WellnessLabsRx NAD+ supplement is a robust choice for those seeking cellular health and energy revitalization.


  • Noticeable increase in day-to-day energy
  • May improve mental clarity and focus
  • Easy to incorporate into a daily routine


  • Effects may vary individually
  • Somewhat pricey compared to other NAD supplements
  • It takes time to observe tangible benefits

Incorporating NAD+ into my daily health regime has been a game-changer; the promise of energy renewal intrigued me, and I felt a discernible uptick in my vitality. Taking two capsules with my morning meal was a cinch, and I appreciated the simplicity of swallowing them without any adverse taste or digestive discomfort. My afternoons often dragged on, but with this supplement, I encountered less of that familiar, sluggish descent.

Skepticism about supplements is typical, but what set this apart was the palpable sharpening of my focus. My desk-bound afternoons were no longer a battle against fatigue and attention span. I noticed an improvement in my cognitive functions, and staying alert no longer required constant caffeine hits. Of course, these observations are subjective, but my experience was quite positive.

Pricewise, the investment into WellnessLabsRx NAD+ was notable. While it may not be the most budget-friendly option on the shelf, the quality appeared to justify the price. As with any supplement regimen, I was patient to see notable changes. So, while the road to these results wasn’t immediate, the gradual improvements in my energy and mental clarity suggested this product was a worthwhile addition to my daily health practices.


I recommend TRU NIAGEN if you’re seeking to enhance your cellular health and energy levels, considering its scientific backing and noticeable effects.


  • Noticeable increase in daily energy and clarity
  • Stringent safety testing and FDA notifications speak to its reliability
  • Positive improvements in healthspan and cellular defense based on my own experience


  • The cost may be prohibitive for some budgets
  • Can cause heart palpitations or digestive issues in some individuals
  • Requires consistent long-term use for significant effects

Having incorporated TRU NIAGEN into my daily routine, I’ve observed a discernible boost in my vitality. The promised elevation in NAD+ levels, which are essential for our cellular functions, appears to hold true based on my improved energy and mental clarity. This suggests that the patented ingredient, Niagen, is working as intended to support my body’s cells.

Despite the range of benefits I’ve experienced, the price point is a consideration that needs to be weighed. It’s at a premium, which may not fit everyone’s budget. Moreover, some reviews mention potential side effects like heart palpitations and stomach discomfort, but these have been absent in my own use.

As for the long-term commitment, patience is key. Those seeking immediate, dramatic results might be disappointed, as the supplement’s full impact unfolds over sustained usage. From my experience, continuous use of TRU NIAGEN is essential to maintain the advantages it brings to my overall well-being.

Redefine Aging with Rossylla NAD+

I’ve found that Rossylla NAD+ stands out with its exceptional combination of potency and absorption, making it a solid investment for anyone serious about cellular health and vitality.


  • High-quality, liposomal NAD+ ensures remarkable absorption and effectivity.
  • A single serving packs a powerful 1300mg punch for noticeable results.
  • Convenient softgel form is a breeze to include in a daily routine.


  • The high potency may be unnecessary for those with less demanding NAD+ needs.
  • Liposomal technology could be costlier compared to standard NAD+ supplements.
  • Being derived from non-GMO soy, it may not suit individuals with soy sensitivities.

Having tried Rossylla myself, I quickly appreciated the convenience of the softgel form. Incorporating it into my daily health regimen required little to no effort. Intuitively, capsule packaging also made it simple to maintain my NAD+ levels whether I was comfortably at home or traveling.

For those of us who value energy and cognitive clarity, the upgraded 1300mg dosage has been a game changer. Each day greeted me with a sustainable energy surge, and I noticed enhanced mental sharpness that lasted throughout my hectic schedule.

While some might be wary of the price tag that often accompanies cutting-edge liposomal formulas, I consider it a worthwhile investment. Rossylla’s commitment to quality and their 100% satisfaction guarantee reassures that every penny spent contributes to one’s wellbeing and longevity objectives.

After several weeks, the promises of heightened energy and age defense were not just marketing claims but my reality. The absence of Rossylla NAD+ from my routine resulted in a discernible dip in vitality, underscoring its tangible benefits.

Elysium Basis NAD+ Booster

I’d recommend this supplement because it delivers notable increases in cellular NAD+ levels, which can be a game-changer for your health and vitality.


  • Noticed invigoration in overall energy
  • Experience of enhanced cellular defense felt reassuring
  • Appreciated the transparent third-party testing


  • Price point might be steep for some
  • No dramatic changes in well-being for me
  • The taste was neutral, albeit unremarkable

After using Elysium Basis, my typical morning felt different; I woke up feeling a bit more alert and ready to tackle my day without the usual grogginess. It’s not every day that you find a product that seems to keep its promise of boosting cellular energy, and I noticed this subtle shift in my routine as I felt livelier and more focused.

There’s something comforting about knowing that the supplement you’re taking is subjected to rigorous testing. The commitment to transparency by Elysium Basis aligns with my preference for open and honest brands. As someone who’s cautious about what I ingest, this level of detail provided me with an extra layer of confidence in the product.

With so many health supplements on the market, it can be challenging to discern what works from what doesn’t. Although I didn’t observe any miraculous changes in my well-being, the overall benefits I experienced from this NAD+ booster make me feel optimistic about its long-term advantages. The commitment to quality ingredients and the research behind Elysium Basis certainly sets it apart.

Maripolio NAD+ Boost

{If energy, DNA repair, and brain function support are priorities for you, Maripolio’s high-potency NAD+ could be a valuable addition to your daily regime.}


  • Remarkably increased my everyday energy without jitters
  • The liposomal delivery seems to enhance absorption significantly
  • Noticed a tangible uptick in cognitive sharpness


  • Two softgels daily might be inconvenient for some people
  • A premium-priced product could be prohibitive for budget-conscious users
  • The size of the softgels could be challenging for those who dislike swallowing pills

In the mornings, I’ve started taking Maripolio NAD+ and have noticed my energy levels are more consistent throughout the day, without the usual mid-afternoon slump. Liposomal technology appears to live up to its promise, as I feel the benefits kick in notably faster. The difference in mental clarity is not subtle; my focus sharpens, and tasks seem a bit less daunting.

However, the necessity of taking two softgels per day means being disciplined about my supplement routine. While I understand that more ingredients might mean larger pills, some users might find the softgel size a bit cumbersome. Despite these considerations, the price seems justified considering the noticeable benefits, but it might not align with everyone’s budget.

Above all, this NAD+ supplement genuinely feels like it’s fueling my body’s energy production and cognitive functions more efficiently. That said, every individual’s response could vary, and I’d advocate for trying Maripolio NAD+ to see if it supports your body as well as it has mine.

Understanding NAD+ and Its Importance

NAD+, or nicotinamide adenine dinucleotide, is a vital molecule in my body’s cellular processes. It plays a critical role in metabolic functions and influences my overall health and aging.

Role of NAD+ in Cellular Metabolism

NAD+ is essential for converting the food I consume into cellular energy. Inside my cells, it functions as a coenzyme in redox reactions, which are the foundation of metabolic processes. These reactions occur in the mitochondria, the powerhouse of the cell, and ensure that my body efficiently converts nutrients into ATP (adenosine triphosphate), which is the primary energy currency of my cells. Without sufficient NAD+, my cellular metabolism could slow down, affecting the energy levels and function of all my cells.

NAD+ and Aging Process

The levels of NAD+ in my body naturally decline with age, which has been linked to various age-related health conditions. Research suggests that reduced NAD+ levels can impair the function of mitochondria, leading to decreased cellular energy production and increased susceptibility to oxidative stress. This decline in NAD+ can potentially accelerate the aging process and affect my body’s ability to repair DNA, further contributing to the development of age-associated diseases.

Benefits of Boosting NAD+ Levels

Boosting NAD+ levels in my body can have multiple benefits, particularly in the context of aging and cellular health:

  • Improved Metabolic Efficiency: By improving the efficiency of my metabolism, I can support my body’s ability to generate energy.
  • Support Cellular Repair: Increased NAD+ can facilitate DNA repair and support the functions of proteins that aid in cellular maintenance.
  • Enhanced Mitochondrial Function: Robust levels of NAD+ help maintain mitochondrial health, which can help sustain my cellular energy levels and potentially delay the onset of metabolic and degenerative diseases.

Ensuring that my body has an ample supply of NAD+ is thus vital to maintaining my metabolism, promoting healthy aging, and supporting overall cellular function.

Types of NAD+ Supplements

NAD+ supplements come in various forms, each with unique properties and methods of delivery to enhance bioavailability. I’ll guide you through the most prominent types currently available.

Best forms of NAD

Nicotinamide Riboside (NR) Supplements

Nicotinamide Riboside, commonly referred to as NR, is a precursor to NAD+ that I have found to be highly bioavailable. It often comes in capsule form. Many patented formulas have been developed to optimize its absorption, and some NR supplements also feature a liposomal delivery method to further enhance bioavailability.

  • Form: Capsules, Powders
  • Bioavailability: High (enhanced with patented formulas)
  • Delivery Method: Liposomal and standard options available

Nicotinamide Mononucleotide (NMN) Supplements

NMN, or Nicotinamide Mononucleotide, is another popular NAD+ precursor. Its stability and structure enable it to effectively raise NAD+ levels in the body. Similar to NR, NMN supplements are available in capsules and sometimes use patented technology to increase their effectiveness.

  • Form: Capsules, Tablets
  • Bioavailability: Optimized with certain patented technologies
  • Delivery Method: Various, including standard and enhanced absorption options

Other NAD Precursors and Boosters

Beyond NR and NMN, there are additional precursors and boosters that support NAD+ synthesis. Although not as widely studied, these compounds can be beneficial. They may come in different supplement formulations and have varying degrees of bioavailability, depending on their chemical structure and the delivery method employed.

  • Forms: Various (including capsules, tablets, and powders)
  • Bioavailability: Depends on specific precursor and formula
  • Delivery Method: Includes standard, liposomal, and other patented methods

Selecting the Best NAD+ Supplement

When choosing an NAD+ supplement, I focus on product quality, appropriate dosage, safety, and brand reputation to ensure that I make an informed decision.

Assessing Quality and Purity

I always begin by examining the purity of NAD+ supplements. It’s crucial to select products that are third-party tested to confirm their purity and to look for certifications such as NSF or GMP that indicate manufacturing standards. I prefer supplements that are non-GMO, gluten-free, and vegan-friendly when possible, to cater to various dietary needs. Here’s a simple checklist for assessing quality and purity:

  • Third-Party Tested: Yes/No
  • NSF Certified: Yes/No
  • GMP Certified: Yes/No
  • Non-GMO: Yes/No
  • Vegan-Friendly: Yes/No
  • Gluten-Free: Yes/No

Considerations for Dosage and Safety

Dosage is another key consideration, and I make sure to follow the recommended amounts provided by clinical research. Safety is paramount, so I ensure that the supplement has a record of safety and look for any potential side effects. Here’s a quick reference for dosage and safety:

  1. Recommended Dosage: (specific mg range per day)
  2. Safety Record: Well-established/Requires further research
  3. Possible Side Effects: Listed/Clear

Comparing Brand Offerings

Finally, I compare different brands for their bioavailability, which affects how well my body can utilize the supplement. I also weigh the cost, as the best NAD+ supplement is one that provides a balance between price and quality. Here’s a brief format to compare brand offerings:

Brand Bioavailability Price Third-Party Testing Notes
A High $$ Yes Best overall value
B Moderate $ No Cost-effective, less evidence of efficacy
C High $$$ Yes Premium product with superior bioavailability

By applying these stringent criteria, I can confidently select the best NAD+ supplement that meets the balance of quality, efficacy, and value.

Health Benefits and Scientific Evidence

In exploring NAD supplements, I’ve found scientific studies focusing on their potential to enhance various biological functions, from slowing the aging process to improving cognitive abilities and metabolic activities.

Impact on Longevity and Aging

Research suggests that NAD+ may help slow the aging process by activating enzymes known as sirtuins, which have been linked to longevity. A study in Cell indicated that increasing NAD+ levels in mice appeared to enhance the function of these enzymes, thus promoting anti-aging effects. Additionally, sirtuins might reduce inflammation, which is associated with age-related diseases.

Enhancing Cognitive Function and Brain Health

NAD+ has a significant role in brain health, with studies showing it may support cognitive function. The Journal of Neuroscience published findings demonstrating that increased NAD levels could protect against age-related decline in brain health. Moreover, clinical trials are investigating NAD+ as a strategy to combat neurodegenerative diseases, owing to its pivotal function in cellular metabolism.

NAD+ in Energy Metabolism and Athletic Performance

The compound is integral to energy metabolism, playing a key part in converting food into cellular energy. This has implications for athletic performance, as a study in Cell Metabolism reported that NAD+ precursors might improve muscle function and exercise capacity. Clinical trials have begun examining the potential of NAD supplements to enhance exercise performance and recovery, providing empirical evidence for its role in energy production and biological processes.

NAD+ Frequently Asked Questions

In this section, I will address some of the most common inquiries about NAD+ supplements. These questions cover their efficacy, safety, and the considerations that you should keep in mind when selecting and using these supplements.

What is a NAD supplement?

NAD supplements are designed to boost levels of Nicotinamide Adenine Dinucleotide (NAD+), a vital coenzyme present in all living cells. NAD+ plays a crucial role in cellular metabolism, energy production, and supporting healthy aging processes. As we age, NAD+ levels naturally decline, leading to metabolic and cellular health issues, which is why supplementation is considered.

Are there any dangers taking NAD supplements?

NAD supplements are generally considered safe for most people when taken as directed. However, potential side effects could include nausea, fatigue, headaches, diarrhea, stomach discomfort, and indigestion. It’s important to consult with a healthcare provider before starting any new supplement regimen, especially for individuals with underlying health conditions or those taking medications.

Do NAD supplements really work?

Evidence suggests that NAD supplements can increase NAD+ levels in the body, potentially offering benefits like improved energy metabolism, enhanced cellular repair, and possibly slowing certain aging processes. However, research is ongoing, and results can vary widely among individuals.

What is the best form of NAD to take?

The best form of NAD to take often depends on individual preferences and goals. Nicotinamide Riboside (NR) and Nicotinamide Mononucleotide (NMN) are the most popular and researched forms of NAD+ precursors available as supplements. Both are effective at raising NAD+ levels, though personal experiences with absorption and efficacy may vary.

What are the top-rated NAD+ supplements currently available?

As I review the market, I find that products like Tru Niagen, Elysium Health’s Basis, and NMN supplements from reputable brands are often highly rated by users. These brands have built a reputation for quality and have undergone various levels of research and testing.

Are the benefits of taking NAD+ supplements backed by scientific evidence?

Yes, there is scientific evidence indicating that NAD+ supplements can support cellular functions and may aid in increasing energy levels, improving cellular repair, and may even have age-related benefits. However, the extent and applicability of these benefits can vary widely among individuals.

What considerations should one make when choosing a brand of NAD+ supplements?

When selecting a brand, I consider the purity of the product, the brand’s reputation, and third-party testing. It’s also important to look at the form of NAD+ provided, whether it’s NR (nicotinamide riboside), NMN (nicotinamide mononucleotide), or another variant, as absorption rates can differ.

What are the potential side effects associated with NAD+ supplementation?

Potential side effects of NAD+ supplementation might include mild to moderate nausea, fatigue, headaches, diarrhea, stomach discomfort, and indigestion. It’s crucial to start with lower doses and monitor your body’s response.

How do NAD+ and NADH supplements differ, and which is preferable for health?

NAD+ is the oxidized form that is essential for metabolism and cellular energy, while NADH is the reduced form used in the production of ATP, the energy currency of the cell. Depending on your health goals, one may be preferred over the other. NAD+ is generally favored for its role in activating sirtuins, which are proteins linked to healthy aging.

Can NAD+ supplements be administered through injections, and are they more effective than oral supplements?

NAD+ supplements can indeed be administered via injections, and some users report more immediate effects. However, the effectiveness of injections over oral supplements is still under investigation. Convenience and cost are also significant factors to consider when choosing between injection and oral supplementation.